Screen Resolution

I haven't read this on any forum, so I was wondering what folks thought about it.

What do you about setting the perfect screen resolution?

I doubt many people still use 800 by 600. I am under the assumption that the average is 1200 by 768? NO?

Well I currently use 1440 by 990 for my personal computer and I am almost certain that most folks do not use that, which means when they view my website, the images will be very large.

Is there a way to have a "fluid" like structure where my website adapts to the resolution set by the visitor's computer?

Or should I pick a resolution and hope that my readers viewing experience is ok?