This morning I upgraded a website to WordPress 3.5, now I notice the menu2 to does not work.

I want to change the category font and size. I had it set to Verdana 14px. I changed the colors,and there were no effect. I change the font size to 48 Px and no effect. I disabled the cache plug-in.
I updated to the latest theme. Atahualpa 3.7.10 .
Disabled all plugins except headspace.
Nothing seems to work. http://ofwtravel.org/

I'm thinking there might be a problem with 3.5

I'm not clear on what isn't working. Also why didn't you deactivate Headspace as a test?

ID de-activated headspace and its the same. I can change the menu2 options, and nothing changes on the display. Right now the menu to option font is set to 48 Px

What do you have in the menu box? I'm not sure if it is a typo but you shouldn't have a space between 48 and px. It should be written as 48px

Font for Category Menu Bar
48px Verdana, sans-serif,Arial

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Background color
F7F10F

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Background color: Hover
CC0000


Nothing matters. I even removed the text box.

It looks like you have the page menu showing. Not the cat menu.