I've been evaluating a number of theme frameworks under the hood for a month or so now.
I'm looking at Genesis, which has very tight code with few calls to the server, but which is not WYSIWYG;
Headway, which doesn't have quite as tight of code but is more WYSIWYG;
iThemes Builder, which has pretty good code and is fairly WYSIWYG;
Hybrid, which again has very good code but requires a good knowledge of CSS;
Gravy, which is more of a design tool,
One of the best articles I've seen that compares 3 of these is this article, the Premium Theme Framework Smackdown. It made me look at things like calls to the server, compliance and mySQL issues.
How does Themeframe compare in these ways? If it's competitive here, that would be awesome. I've been happily using Atahualpa for a year on a couple of different sites.