You could use all the sidebars plue add new widget areas to the loop (See ATO>Add New Widget Areas) or you could use the Widgets on Pages plugin
. There may be other creative solutions as well.
For the different look and feel you can get creative with CSS for specific pages if you used the Widgets on Pages plugin or you could style the widgets with conditionals.
There is now simple answer that I can think of for doing what you want. It is a matter of becoming familiar with WordPress, Atahualpa, CSS, and perhaps some PHP and getting creative.
Sorry... The above applies to Atahualpa and not Themeframe. I read the title but now what forum it was in.